THERAPEUTIC DIET: THE ROLE OF WHOLE-FOODS AND PLANT-BASED DIET IN AUTOIMMUNE DISEASES MODULATION

Abstract

Autoimmune diseases represent a diverse group of chronic conditions marked by immune system dysfunction, with rising prevalence globally. Emerging evidence suggests that diet plays a pivotal role not only in symptom modulation but also in potentially altering disease progression. This review explores the clinical and mechanistic implications of whole-Foods and plant-based diets as a therapeutic strategy for managing autoimmune conditions. Drawing on data from observational studies, randomized controlled trials, and individual case reports, it examines the impact of dietary interventions on diseases such as rheumatoid arthritis, type 1 diabetes, multiple sclerosis, inflammatory bowel disease, systemic lupus erythematosus, and psoriatic arthritis. Findings consistently point to reductions in inflammatory markers, improved gut microbiota profiles, and attenuation of disease symptoms. While complete reversal of autoimmune pathology remains uncertain, the data support whole-Foods and plant-based diets as a sustainable, adjunct approach capable of enhancing clinical outcomes. The review also addresses implementation challenges and emphasizes the need for further large-scale research to validate these preliminary findings and optimize dietary recommendations within personalized treatment frameworks.