FABRICATION OF HYPERTHERMIA EFFICIENCY MEASUREMENT SYSTEM BASED ON AN ALTERNATING MAGNETIC FIELD

Abstract

The development of magnetic hyperthermia machines is also necessary in the exact description of the heating performance of the magnetic nanoparticles (MNPs) in the presence of alternating magnetic fields (AMFs). The paper presents a report of the design, fabrication, and validation of a low-set up cost, versatile AMF system designed to produce sinusoidal and non-sinuoidal waveforms (triangular, trapezoidal, trapezoidal- triangular and sawtooth). The fabricated apparatus incorporates a full-bridge inverter AMF generator, maximized copper induction coil, fiber optic temperature detection apparatus as well as a thermally insulated three-layer calorimeter to be precisely measured. Superparamagnetic iron oxide nanoparticles (SPIONs) produced through Massart co-precipitation technique was assessed on heating performance under controlled conditions of AMF. Findings indicated how the non-sinusoidal waveforms greatly increased the heating efficiency such that the SAR was up to 45 percent higher than when using the conventional sinusoidal waveform with 200 kHz and 2.14 mT. This system showed a linear behaviour to the change in magnetic field intensity, frequency and concentration of nanoparticles, which demonstrates high stability and reproducibility of the system. Also, the analysis of waveforms indicated that it was logarithmically correlated that field rise rate was related to thermal power dissipation. Proved to be a cost-effective as well as flexible substitute to commercial systems, this open-source and modular format can allow promote deeper studies into magnetic heating systems and AMF optimization aimed at biomedical and material science purposes.