THERAPEUTIC POTENTIAL OF AJWAIN (TRACHIPTERUS AMMI) AGAINST DIET-INDUCED OBESITY AND DYSLIPIDEMIA IN RAT

Abstract

The aim of present study was to assess the protective effect of carom seed powder against obesity and hyperlipidemia by using animal model. Sixteen rats were given high-fructose and high-fat diet to induce obesity, then powder of carom seeds was given to the treatment groups, G₁, G₂ and G₃ according to their per kg body weight are about to 100 mg, 300 mg and 500 mg respectively. This trial period was continued for 6-weeks on daily basis. During this practice serum leptin, blood glucose and lipid profile were checked 0, 21 and 42 day and anthropometric measurements were taken 0, 21, 28, 42 days. The data thus obtain was analyzed statistically. The effect was seen in G₃ (500 mg carom powder) that reduced low density lipoprotein cholesterol (69.75 mg/dl to 57.50 mg/dl), triglycerides (50.75 mg/dl to 39.50 mg/dl), total cholesterol (79.01 mg/dl to 42.25 mg/dl), serum leptin (19.20 ng/ml to 13.57 ng/ml), serum blood glucose (119.0 mg/dl to 78.75 mg/dl), body weight (213.9 g to 179.1 g) and body mass index (151.32 g/cm² to 140.10 g/cm²). The data has shown significant decreased in LDL, triglycerides, cholesterol, blood glucose, serum leptin and body weight while significant increase in high density lipoprotein HDL (20.01 mg/dl to 25.06 mg/dl) due to uptake of carom powder. It is concluded from present study that carom powder has ability to influence the above-described obesity biomarkers. Concisely, carom powder has the quality to lower the causes of some metabolic ailments such as hyperlipidemia and hyperglycemia complications.